General Information

  • ID:  hor006310
  • Uniprot ID:  Q8BFS3
  • Protein name:  Relaxin-3 B chain
  • Gene name:  Rln3
  • Organism:  Rattus norvegicus (Rat)
  • Family:  Insulin family
  • Source:  animal
  • Expression:  Highly abundant expression is detected in neurons within the ventomedial dorsal tegmental nucleus and the laterally central gray alpha of the pons. Also detected at much lower levels within the hippocampus.
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:   Rattus (genus), Murinae (subfamily), Muridae (family), Muroidea , Myomorpha (suborder), Rodentia (order), Glires , Euarchontoglires (superorder), Boreoeutheria , Eutheria , Theria , Mammalia (class), Amniota , Tetrapoda , Dipnotetrapodomorpha , Sarcopterygii (superclass), Euteleostomi , Teleostomi , Gnathostomata , Vertebrata , Craniata (subphylum), Chordata (phylum), Deuterostomia , Bilateria , Eumetazoa , Metazoa (kingdom), Opisthokonta , Eukaryota (superkingdom),cellular organisms
  • GO MF:  GO:0001664 G protein-coupled receptor binding; GO:0005179 hormone activity
  • GO BP:  GO:0007165 signal transduction
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  RPAPYGVKLCGREFIRAVIFTCGGSRW
  • Length:  27(24-50)
  • Propeptide:  MATRGLLLASWALLGALVLQAEARPAPYGVKLCGREFIRAVIFTCGGSRWRRADILAHDPLGEFFADGEANTDHLASELDEAVGSSEWLALTKSPQVFYGGRSSWQGSPGVVRGSRDVLAGLSSSCCEWGCSKSQISSLC
  • Signal peptide:  MATRGLLLASWALLGALVLQAEA
  • Modification:  NA
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  May play a role in neuropeptide signaling processes. Ligand for LGR7, relaxin-3 receptor-1 and relaxin-3 receptor-2 (By similarity).
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  Rxfp1, Rxfp3
  • Target Unid:  Q6R6I6, Q5Y986
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  NA

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor006310_AF2.pdbhor006310_ESM.pdb

Physical Information

Mass: 350453 Formula: C138H215N41O33S2
Absent amino acids: DHMNQ Common amino acids: GR
pI: 10.45 Basic residues: 5
Polar residues: 9 Hydrophobic residues: 10
Hydrophobicity: 5.56 Boman Index: -3708
Half-Life: 1 hour Half-Life Yeast: 2 min
Half-Life E.Coli: 2 min Aliphatic Index 72.22
Instability Index: 5659.26 Extinction Coefficient cystines: 7115
Absorbance 280nm: 273.65

Literature

  • PubMed ID:  12354304
  • Title:  Restricted, but abundant, expression of the novel rat gene-3 (R3) relaxin in the dorsal tegmental region of brain.
  • PubMed ID:  12686464
  • Title:  Production of recombinant human relaxin 3 in AtT20 cells.